ESTRO 2024 - Abstract Book

S988

Clinical - Gynaecology

ESTRO 2024

Conclusion:

Our study demonstrated that the fat fraction of BM located inside the radiation field of women with LACC increased during chemoradiotherapy and remains high after treatment, whereas the fat composition of BM outside the radiation field remains at stable level. Despite the use of PB sparing VMAT, the fat content of all three regions of the PB increased and all women in this study developed acute lymphopenia grade 2+. Further follow up of this patient group will yield more knowledge about the effect of PB sparing chemoradiotherapy on BM fat changes and HT. Additionally, the PB sparing proton therapy phase of the PROTECT study will facilitate the comparison of BM dose, BM fat component, and HT between proton and photon therapy.

Keywords: cervical cancer; bone marrow fat; lymphopenia

References:

1. Corbeau A, Nout RA, Mens JWM, Horeweg N, Godart J, Kerkhof EM, et al. PROTECT: Prospective Phase-II Trial Evaluating Adaptive Proton Therapy for Cervical Cancer to Reduce the Impact on Morbidity and the Immune System. Cancers. 2021;13(20):5179.

2. McGuire SM, Menda Y, Ponto LLB, Gross B, TenNapel M, Smith BJ, et al. Spatial mapping of functional pelvic bone marrow using FLT PET. Journal of applied clinical medical physics. 2014;15(4):129-36.

3. Mell LK, Kochanski JD, Roeske JC, Haslam JJ, Mehta N, Yamada SD, et al. Dosimetric predictors of acute hematologic toxicity in cervical cancer patients treated with concurrent cisplatin and intensity-modulated pelvic radiotherapy. International Journal of Radiation Oncology*Biology*Physics. 2006;66(5):1356-65.