ESTRO 2025 - Abstract Book

S1099

Clinical – Head & neck

ESTRO 2025

Conclusion: Consistent with findings from previous studies (1,2), our data confirm that MRI provides superior precision in delineating the pharyngeal constrictor muscle (PCM) and spinal cord compared to ceCT, while ceCT remains more effective for mandible delineation. Ongoing work includes extending the analysis to the full patient cohort, incorporating target volume delineation. Additionally, efforts are underway to develop a fully automated solution leveraging artificial intelligence for MR-based delineation of organs at risk (OARs) and target volumes in head and neck tumors. References: 1.Paczona VR et al. Magnetic Resonance Imaging-Based Delineation of Organs at Risk in the Head and Neck Region. Adv Radiat Oncol. 2022 Jul 30;8(2):101042. doi: 10.1016/j.adro.2022.101042. PMID: 36636382; PMCID: PMC9830100. 2.Pigorsch SU et al. MRI- and CT determined changes of dysphagia/aspiration-related structures (DARS) during and after radiotherapy. PLoS ONE. 2020;15(9): e0237501. 3.Brouwer CL et al. CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines. Radiother Oncol. 2015 Oct;117(1):83-90. doi: 10.1016/j.radonc.2015.07.041. Epub 2015 Aug 13. PMID: 26277855. Digital Poster Quality of life and financial toxicity in head and neck cancer patients treated with particle therapy: a prospective study (NCT05947149) Anna Maria Camarda 1 , Carmine Tinelli 2 , Federica Serra 3 , Nadia Facchinetti 3 , Viola Ghio 3 , Rossana Ingargiola 1 , Sara Ronchi 1 , Maria Bonora 1 , Barbara Vischioni 1 , Lisa Licitra 4,5 , Ester Orlandi 1,6 1 Radiation Oncology Unit, Clinical Department, CNAO National Center for Oncological Hadrontherapy, Pavia, Italy. 2 Scientific Direction, CNAO National Center for Oncological Hadrontherapy, Pavia, Italy. 3 Clinical trial center, CNAO National Center for Oncological Hadrontherapy, Pavia, Italy. 4 Head and Neck Medical Oncology, Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan, Italy. 5 Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy. 6 Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy Purpose/Objective: Quality of life (QoL) represents a fundamental issue in the care of head and neck cancer (HNC). Many studies have focused on QoL in conventional radiotherapy but there is still a lack of data after particle therapy (PT) (1). In addition, financial toxicity (FT) is very crucial in these pts both for the costs of medical care and for the symptoms reported (2). Our aim is to collect QoL and FT data by questionnaires and to investigate their relationships with socio-cultural and clinical variables. Material/Methods: This prospective study will include pts with HNC candidate to PT. Pts will be enrolled at the first session of PT. Exclusion criteria are: re-irradiation, second tumor, psychiatric and neurological diseases. Questionnaires EORTC QLQ-C30 will be administered at baseline, 3, 6 months and 1 year after PT and PROFFIT at baseline and 1 year after PT. Descriptive statistics were generated for clinical factors, QoL and FT. Associations with clinical and/or social factors were performed with t-test, anova one-way analysis or chi square test. R Pearson Correlation was used for correlation between age and socio-cultural factors. Results: From May 2023 to October 2024 sixty-two pts have been enrolled. Pts’ characteristics are listed in Figure 1. All pts completed the questionnaires at baseline (T0) and thirty-five completed at 3 months (T1) after PT. Mean scores are Keywords: MRI, head and neck, radiotherapy 3788