ESTRO 2025 - Abstract Book

S1189

Clinical – Lower GI

ESTRO 2025

Conclusion: The majority of frail and elderly patients, receiving 30Gy for ASCC, had a complete response or died with or without disease of other causes. This data will be used in collaboration with patient representatives to inform the design of future trials by the PLATO group in this poorly researched population, particularly in terms of proposed doses and appropriate endpoints.

Keywords: Frail, comorbid, anal cancer

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Digital Poster Quality of Life Assessment in Czech Patients with Anal Cancer: A Multicentre Study Using the EORTC QLQ C30, QLQ-ANL27 and LARS questionnaires Radka Lohynská 1,2 , Zdeňka Pechačová 3,4 , Kateřina Ťukalová 5 , Michaela Jirkovská 6,7 , Eva Skácelíková 8,9 1 Department of Oncology, Thomayer University Hospital, Prague, Czech Republic. 2 1st Faculty of Medicine, Charles Univesity, Prague, Czech Republic. 3 Institute of Radiation Oncology, Bulovka University Hospital, Prague, Czech Republic. 4 1st Faculty of Medicine, Charles University, Prague, Czech Republic. 5 Department of Oncology, Hospital Liberec, Liberec, Czech Republic. 6 Department of Oncology, University Hospital Motol, Prague, Czech Republic. 7 2nd Faculty of Medicine, Charles Univesity, Prague, Czech Republic. 8 Department of Oncology, University Hospital Ostrava, Ostrava, Czech Republic. 9 Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic Purpose/Objective: The EORTC QLQ-ANL27 questionnaire, developed in 2022, was translated into Czech and adapted for the Czech population in 2023, following EORTC Guidelines. The use of validated international questionnaires to assess quality of life is an essential aspect of measuring the effectiveness of oncological treatments. Material/Methods: A multicenter study assessing the quality of life following radiotherapy or chemoradiotherapy for anal cancer was conducted across five Comprehensive Cancer Centres in the Czech Republic between 2023 and 2024. The evaluation employed the LARS (Low Anterior Resection Syndrome) questionnaire alongside the EORTC QLQ-C30 and QLQ-ANL27 tools.