ESTRO 2025 - Abstract Book

S1190

Clinical – Lower GI

ESTRO 2025

Results:

A total of 140 patients were evaluated using questionnaires post-treatment. The cohort had an average age of 62 years, with women comprising 84% of the group. Most cases were classified as clinical stage III. The mean LARS score was 27.7 (indicating minor LARS). In the EORTC QLQ-C30, the functional score averaged 82.3, the symptom score 18.5, and the global health score 63.4. The EORTC QLQ-ANL27 yielded a functional score (sexual function) of 40.3 and a symptom score of 25.6. A correlation was observed between the LARS and the ANL-27 symptom score: patients without LARS had a ANL-27 mean symptom score of 9, those with minor LARS scored 19 in ANL-27, and those with major LARS scored 33 in ANL-27 questionnaire. Conclusion: Patient, tumour, and treatment characteristics significantly impacted quality-of-life scores after radical radiotherapy, highlighting the multifactorial influence of clinical and lifestyle factors on patient outcomes. The LARS questionnaire correlates with ANL-27 and can serve as a valuable tool for the rapid assessment of anorectal function. Supported by grants from the Ministry of Health of the Czech Republic – RVO (Thomayer University Hospital – FTN, 00064190) and The National Institute for Cancer Research Project (Programme EXCELES, ID Project No. LX22NPO5102) - Funded by the European Union - Next Generation EU. References: Sodergren SC, et al; European Organisation for Research and Treatment of Cancer Quality of Life Group. International Validation of the EORTC QLQ-ANL27, a Field Study to Test the Anal Cancer-Specific Health-Related Quality-of-Life Questionnaire. Int J Radiat Oncol Biol Phys. 2023;115(5):1155-1164 Emmertsen KJ, et al. Low anterior resection syndrome score: development and validation of a symptom-based scoring system for bowel dysfunction after low anterior resection for rectal cancer. Ann Surg. 2012;255(5):922-8 Sauter C, et al. Quality of life in patients treated with radiochemotherapy for primary diagnosis of anal cancer. Sci Rep. 2022;12(1):4416 Keywords: anal cancer, quality of life, radiotherapy