ESTRO 2025 - Abstract Book

S1656

Clinical – äediatric tumours

ESTRO 2025

relapse-free survival, distant metastasis-free survival, and overall survival rates were 97.1%, 88.2%, and 88.2%, respectively. Acute toxicities commonly included grades 3–4 hematologic toxicities and stomatitis. Late toxicities were observed in nearly 42% of cases, primarily including xerostomia and trismus, as well as tinnitus, hearing loss, and dental pain. Among the 34 patients who survived more than 2 years, 40% and 39% developed grades 1–2 xerostomia and trismus, respectively Conclusion: IMRT combined with chemotherapy provides excellent long-term locoregional control in pediatric and adolescent NPC. However, distant metastasis remains the main mode of treatment failure. Among late complications, xerostomia and trismus are the most frequently observed . Continued follow-up is essential to manage these complications and improve supportive care strategies for survivors

Keywords: Toxicities Pediatric Nasopharyngeal Radiotherapy

4538

Mini-Oral Adult survivors of childhood cancers: own experience Aleksandra Napieralska 1,2 , Katarzyna Drosik-Rutowicz 3,2 , Aleksandra Król 4 , Krzysztof Składowski 3

1 Radiotherapy Department, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice, Poland. 2 Radiotherapy Clinic, Maria Skłodowska-Curie National Research Institute of Oncology, Cracow, Poland. 3 Ist Radiotherapy Clinic, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice, Poland. 4 Department of Nuclear Medicine and Endocrine Oncology, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice, Poland Purpose/Objective: Over 80% of children diagnosed with cancer live over 5 years after the end of therapy. Childhood cancer survivors can experience a lot of persistent side effects and disabilities after the end of treatment, and the number of complications increase with the time since diagnosis. There is a lack of specialized centres for adults who received cancer treatment during their childhood in Poland. Material/Methods: A dedicated clinic for young adults with childhood cancer history was opened in July 2022. The information regarding their health and social aspects was collected. The incidence of subsequent cancers and treatment late toxicity was evaluated. Results: Since 2022, 135 patients (69 male, 66 female) were provided with multidisciplinary care. The median age of diagnosis was 14 years old (range 1-18). The majority of patients were from regional (64%) or nearby (17%) parts of Poland, however 19% came from distant regions. Primary diagnosis included: brain tumours (33%), lymphoma (28%), leukaemia (14%), sarcoma (13%), testicular/ovary tumours (5%), renal tumours (4%) and others (3%). Surgery, chemotherapy, radiotherapy and transplantation were implemented in primary treatment in 55%, 85%, 53% and 2%, respectively. Patients were referred to our clinic as a continuation of childhood cancer treatment (6%) or during the short (less than 5 years - 48%) or long (more than 5 years -39%) follow-up after the end of cancer therapy. In 6% progression of the primary disease or subsequent cancer was diagnosed and treated. Second, third and fourth subsequent cancer were diagnosed in 8, 3 and 1 patient, respectively.