ESTRO 2025 - Abstract Book

S1724

Clinical - Sarcoma & skin cancer & malignant melanoma

ESTRO 2025

No G4-G5 toxicity was observed. Two patients had G3 toxicity (esophagitis and dermatitis). Reported G2 toxicity was as follows: enteritis (1), gastritis (1),nauseas (1), dermatitis (1). All eleven patients with symptoms before the treatment (dyspnea, pain, anemia, edema and constipation) presented symptom’s relief.

Based on RECIST1.1criteria, ten patients (67%) had stable local disease. Five patients (33%) had local progression. After RT, surgical resection was feasible in five patients.

Three patients are alive with stable disease (at 21,22 and 32 months of follow-up); three are alive with disease, three of operated patients are alive and without disease, six patients died of metastatic progression. One-year overall survival rate was 43% and one-year local recurrence free survival rate was 49%. See figures 1 and 2. Conclusion: In inoperable bulky soft-tissue sarcomas Lattice is feasible and well tolerated. Further studies are needed to assess the impact on clinical outcome

Keywords: Lattice sarcoma

References: M. P. Grams et al. , “VMAT Grid Therapy: A Widely Applicable Planning Approach,” Pract. Radiat. Oncol. , vol. 11, no. 3, pp. e339–e347, May 2021

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Mini-Oral Cosmetic outcome and patient satisfaction after radiotherapy of Squamous Cell Carcinomas (SCC) of the skin - a multi-institutional prospective study Jesper G Eriksen 1,2 , Oscar N Brændstrup 1 , Pernille Lassen 3 , Steen R De Blanck 4 , Jeppe Friborg 4 , Camilla K Lonkvist 3 , Anni L Nielsen 3 , Hanne Primdahl 2 , Gulalai Hanan 5 , Mamadi Toure 5 , Maria Andersen 6 , Kinga Nowicka-Matus 6 , Rasmus Kjeldsen 6 , Anita B Gothelf 4 1 Dept. of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark. 2 Dept. of Oncology, Aarhus University Hospital, Aarhus, Denmark. 3 Dept. of Oncology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. 4 Dept. of Oncology, Copenhagen University Hospital, Copenhagen, Denmark. 5 Dept. of Oncology, Vejle Hospital, Vejle, Denmark. 6 Dept. of Oncology, Aalborg University Hospital, Aalborg, Denmark Purpose/Objective: Non-melanoma skin cancer (NMSC) is the most frequent cancer world-wide and primarily treated with surgery. However, for head and neck NMSC radiotherapy (RT) is a valid option in case surgery is not possible or due to either patient preference or cosmetic reasons. In Denmark the incidence of NMSC is increasing with estimated 40.000 new cases a year – less than 20% being squamous cell carcinomas (SCC). Only a subset is treated with RT. Aim of the present study was to describe the cohort of patients treated with RT for primary head and neck skin SCC and the cosmetic results evaluated by healthcare professionals and the patients themselves six months after end of treatment. Material/Methods: Patients with skin SCC in the head and neck region consecutively referred for RT between January 1 st 2019 and December 31 st 2023 in five of six Danish centers were included in the study. Patients were offered a follow-up six months after completion of treatment for cosmetic evaluation. Patient-reported satisfaction with cosmetic outcome was scored as: very satisfied, satisfied, indifferent, or unsatisfied. Professional scoring was based on LENTSOMA criteria with an overall cosmetic score reported as: no, minor, major, or disfiguring skin changes compared to the surrounding skin.