ESTRO 2025 - Abstract Book

S2323

Interdisciplinary – Health economics & health services research

ESTRO 2025

Conclusion: No statistically significant or clinically relevant impact of proton versus photon therapy on HRQoL was observed. The potential role of selection bias remains unclear, provided proton therapy eligibility is determined based on higher anticipated risk of radiation-induced toxicity (model-based approach).

Keywords: Proton, Utility, Lung

References: Käsmann, Lukas et al. “Radiation-induced lung toxicity - cellular and molecular mechanisms of pathogenesis, management, and literature review.” Radiation oncology (London, England) vol. 15,1 214. 10 Sep. 2020, doi:10.1186/s13014-020-01654-9 Bourke, Siobhan et al. “Estimating the minimally important difference for the EQ-5D-5L and EORTC QLQ-C30 in cancer.” Health and quality of life outcomes vol. 22,1 81. 20 Sep. 2024, doi:10.1186/s12955-024-02294-3 Musoro, Jammbe et al. “Minimally important differences for interpreting EORTC QLQ-C30 change scores over time: A synthesis across 21 clinical trials involving nine different cancer types.” European journal of cancer (Oxford, England : 1990) vol. 188 (2023): 171-182. doi:10.1016/j.ejca.2023.04.027

Made with FlippingBook Ebook Creator