ESTRO 2025 - Abstract Book

S2325

Interdisciplinary – Health economics & health services research

ESTRO 2025

On the second graph, the orange curve shows cancer cases in men with regular PET screening, while the red curve shows mortality, including radiation from PET. The blue curve represents detected cases, and the green curve shows cured cases. After age 70, detection and curing level off due to the cessation of regular PET screenings beyond this age. Conclusion: We found that regular PET screenings contribute to curing a significant number of cancers through early detection, although they also increase cancer incidence due to radiation exposure. This leads to an 18% rise in cancer incidence and a 38% reduction in mortality, emphasizing the life-saving role of PET screenings. The research was partially supported by The National Research Foundation of Ukraine under the project "Improving Quality and Safety in Radiation Therapy for Cancer and Radiological Diagnostics" (registration number 2021.01/0211, Science for Safety and Sustainable Development of Ukraine).

Keywords: Early cancer detection, excess absolute risk References:

[1] National Cancer Institute. (2021). DevCan: Cancer survival statistics (Version 6.7.6) [Computer software]. U.S. Department of Health and Human Services, National Institutes of Health. https://surveillance.cancer.gov/devcan/ [2] National Research Council. (2006). Health risks from exposure to low levels of ionizing radiation: BEIR VII phase 2 (The National Academies Press). https://doi.org/10.17226/11340

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Digital Poster Cost-Effectiveness of Hypofractionation in Radiotherapy: Optimizing Resources and Access. Miguel Espindola 1,2 , Micaela Motta 2 , Angelo Di Naro 2 , Michele Sala 3 , Francesco Romeo Filippone 2 , Fabio Peroni 4 , Giulia Rinaldi 2 , Elisabetta Vitali 2 , Suela Vukcaj 2 , Fabio Piccoli 2 , Roberta Muni 2 , Laura Maffioletti 2 , Stefano Andreoli 4 , Maurizio Portaluri 2