ESTRO 2025 - Abstract Book

S3718

Physics - Radiomics, functional and biological imaging and outcome prediction

ESTRO 2025

further analysis. The occurrence of RE2+ (44%) was comparable to that of the development cohort [1]. None of the clinical factors significantly correlated with RE2+. The average DVHs of patients with and without RE2+ showed a significant separation between the two curves starting from 10 Gy (Figure 1). The relative esophageal volume receiving at least 55 Gy (V 55Gy ) confirmed to be a good predictor in external validation (AUC-ROC=0.67 95%CI 0.61 0.72). The VBA identified regions of significant association between BED and RE2+ in a region encompassing the thoracic esophagus, with the most significant region matching the middle thoracic esophageal segment (Figure 2). The overlap with significant esophageal regions previously identified was satisfactory (Dice over volume=0.7).