ESTRO 2025 - Abstract Book

S584

Clinical - Breast

ESTRO 2025

Material/Methods: Between 01/2010 and 02/2024, 104 breast cancer patients with local recurrence were treated with surgery followed by re-RT.Acute toxicity was graded according to toxicity criteria of the RTOG.The KaplaneMeier method was used for survival analysis, and Cox regression analysis was used for univariate and multivariate analysis. Results: 104 patients were identified who underwent reirradiation for locoregionally recurrent invasive breast cancer,with a median follow-up of 46 months.Seven patients experienced local recurrence after re-irradiation. The total dose after dose summation ranged from 97Gy to 112Gy. Six patients (6%) developed grade 3 or higher acute radiation-induced lung injury (five cases of grade 3, one case of grade 4). In univariate analysis, the mean lung dose (MLD) and V5 of the fused plan were significantly associated with grade 3 or higher acute radiation-induced lung injury (P < 0.05). Five patients developed grade 3 or higher acute radiation-induced heart injury; in univariate analysis, the maximum heart dose (MHD), V5, V10, and V20 of the fused plan were significantly associated with grade 3 or higher acute radiation-induced heart injury (P < 0.05). In multivariate analysis, the maximum heart dose (MHD) of the fused plan was significantly associated with grade 3 or higher acute radiation-induced heart injury (P < 0.05). The rate of grade 3 or higher radiation dermatitis was 8%. Conclusion: Re-irradiation after the initial radiotherapy for patients with local recurrence of breast cancer is feasible, and the complications occurring during re-irradiation are acceptable. The local tumor control and overall survival rates are encouraging. Digital Poster Exploring pain management in breast cancer: key findings from the prospective ARISE study. Costanza Maria Donati 1,2 , Erika Galietta 1,2 , Letizia Cavallini 2,1 , Fracnesco Cellini 3,4 , Alice Zamagni 2 , Francesco Deodato 4,5 , Gabriella Macchia 5 , Silvia Cammelli 2,1 , Milly Buwenge 2 , Mira Huhtala 6 , Martijn Boomsma 7 , Fracnesca De Felice 8 , Alessio Giuseppe Morganti 2,1 , Savino Cilla 9 1 Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. 2 Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy. 3 Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy. 4 Dipartimento Universitario Diagnostica per immagini, Radioterapia Oncologica ed Ematologia, Università Cattolica del Sacro Cuore, Rome, Italy. 5 Radiotherapy Unit, Gemelli Molise Hospital, Catholic University of Sacred Heart, Campobasso, Italy. 6 Department of Oncology, Turku University Hospital, Turku, Finland. 7 Department of Radiology, Isala Hospital, Zwolle, Netherlands. 8 Department of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, Italy. 9 Medical Physics Unit, Responsible Research Hospital, Gemelli Molise Hospital, Campobasso, Italy Purpose/Objective: This ARISE study secondary analysis aims to delve into the complexities of pain management in breast cancer patients undergoing radiotherapy (RT) in Italy, seeking to understand the multifaceted factors that contribute to the prevalent inadequacy in pain management. It aims to identify and analyze predictive variables for pain management adequacy and establish the relationship between these variables and the effectiveness of pain control. Keywords: reirradiation,local recurrence ,radiation toxicity 3567

Material/Methods: This observational study engaged 2,104 participants from 13 Italian RT departments, focusing on 426 breast cancer