ESTRO 2025 - Abstract Book

S684

Clinical - CNS

ESTRO 2025

Conclusion: This review underscores significant inconsistencies in the terminology and definitions used to describe MRI alterations following RT, limiting the generalizability of findings across studies. Our results highlight the need for the development of a standardized framework for describing MRI alterations after RT. Such framework will facilitate meaningful comparison of large datasets, essential to draw robust conclusions about the impact of radiation modality on MRI alterations. Additionally, these standardized datasets will support further research into the potential role of PT associated factors beyond dose, such as LET, in MRI alterations after PT. This framework will be developed by neuro-oncology radiotherapy experts within the EPTN, in collaboration with radiology specialists in neuro-oncology ensuring multidisciplinary applicability.

Keywords: MRI alterations, proton therapy, EPTN

References: Not Applicable

1962

Digital Poster Gamma Knife radiosurgery for sporadic vestibular Schwannoma: volumetric response analysis Chiara Mattioli 1 , Isacco Desideri 1 , Daniela Greto 1 , Guido Pecchioli 2 , Luca Visani 1 , Carlotta Becherini 1 , Gabriele Simontacchi 1 , Alessandra Galardi 1 , Beatrice Bettazzi 1 , Carolina Orsatti 1 , Doruntina Cela 1 , Lorenzo Livi 1 1 Radiation Oncology, Azienda Ospedaliero Universitaria Careggi, Università di Firenze, Firenze, Italy. 2 Neurosurgery Unit, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence, Italy Purpose/Objective: Stereotactic radiosurgery (SRS) is the standard treatment for vestibular Schwannoma (VS), including as a primary therapy, adjuvant treatment after incomplete surgery, or for recurrence. The main goal is local control (LC), minimizing the need for additional interventions. Preserving hearing and facial nerve function, and managing