ESTRO 2025 - Abstract Book

S748

Clinical - CNS

ESTRO 2025

stability. Ultimately, this contributes to the dual goals of treatment precision and the humanization of pediatric oncology care.

Keywords: Pediatric, Radiomics, Humanization

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Digital Poster Impact of radiotherapy on verbal memory: short and long-term effects in cerebral meningioma patients Karan Jangbahadoer Sing 1 , Eva Mulder 2 , Catharina M.L. Zegers 1 , Marvin Ribeiro 1 , Wouter van Elmpt 1 , Daniёlle B.P. Eekers 1 1 Radiation Oncology, Maastro, Maastricht, Netherlands. 2 ENT/Audiology, Maastricht University Medical Centre+, Maastricht, Netherlands Purpose/Objective: Meningiomas are benign, slow-growing brain tumors treated with surgery or radiotherapy [1]. Radiotherapy is associated with deficits in memory, attention, executive function, and verbal fluency [2]. Understanding dose response relationships is key to minimizing cognitive decline. This pilot study examines the relationship between radiotherapy dose and cognitive decline in patients with benign meningioma (WHO I), using data from the prospective PRECODE (PREselection of patients at risk for Cognitive Decline) study (NTC04638478). The aim was to assess cognitive changes post-radiotherapy by evaluating neuropsychological test outcomes in relation to treatment parameters like mean brain dose and gross tumor volume (GTV). Material/Methods: Cognitive assessments were conducted for 11 patients at baseline, 3 months, and 2 years post-treatment. Verbal memory and working memory were evaluated using the Hopkins Verbal Learning Test – Revised (HVLT-R), focusing on the Total Recall score, which measures retention of verbal information. Cognitive changes were quantified using Reliable Change Indices (RCI). The RCI calculated between baseline and 3 months reflects short-term cognitive changes, while the RCI between baseline and 2 years provides insight into long-term changes. Factors such as age, education level, and tumor volume were considered to account for natural variability.

Results: