ESTRO 2025 - Abstract Book

S749

Clinical - CNS

ESTRO 2025

Short-term RCI scores (Figure 1A) show high variability, reflecting mixed cognitive effects 3 months after radiotherapy, including transient declines and improvements. Long-term RCI scores (Figure 1B) cluster closer to zero, suggesting recovery or stabilization. Despite initial short-term memory impairments, the brain may adapt and compensate for radiation-induced deficits. The lack of a clear correlation between mean brain dose and RCI scores in both plots highlights individual variability, suggesting that non-dose factors, such as age and tumor characteristics, play a critical role in cognitive outcomes. Patients with larger GTV volumes (Figure 2) show a positive change in RCI values over time, indicating improved cognitive function at the two-year follow-up. This suggests that the initial presence of a larger slowly growing tumor may have contributed to cognitive issues, potentially due to elevated intracranial pressure, which impairs memory [5]. Over the years, reduction in tumor size following treatment could correlate with cognitive improvement. Conclusion: This study highlights a relationship between radiation dose, GTV, and verbal memory changes. While these findings provide preliminary insights, the small sample size underscores the need for further research with larger cohorts to validate trends and guide personalized radiotherapy approaches aimed at reducing cognitive risks. Future studies should explore additional factors influencing cognitive outcomes, such as treatment regimen and patient-specific characteristics. References: [1] Minniti, G., et al., (2009). Radiotherapy and radiosurgery for benign skull base meningiomas. Radiation Oncology , 4, p.42. [2] Monje, M. L., & Palmer, T. (2003). Radiation injury and neurogenesis. Current opinion in neurology, 16(2), 129 134. [3] Goldbrunner, R., et al. (2016) EANO Guidelines for the Diagnosis and Treatment of Meningiomas. Lancet Oncol. 7, e383–e391. [4] Gondar, R., et al. (2021). Meningiomas and cognitive impairment after treatment: a systematic and narrative review. Cancers, 13(8), 1846. [5] Grech, O., et al. (2021). Cognitive performance in idiopathic intracranial hypertension and relevance of intracranial pressure. Brain Communications , 3(3) Keywords: Meningioma, Radiotherapy, Cognition