ESTRO 2025 - Abstract Book

S816

Clinical - Gynaecology

ESTRO 2025

Results:

A total of 501 patients were evaluated, with a median age of 72 years. The majority (64.6%) had no comorbidities, and 80% had an optimal performance status (ECOG: 0). RT alone was performed as exclusive treatment in 39.1% of patients and a sequential or concomitant systemic therapy was administered to 60.9% of patients. Only 16% of patients reported RT-related fatigue. At T1, fatigue was noted in 9.4% (CLAS1), 13.6% (CLAS2), and 13.2% (CLAS3); at T2, the rates were 13.2%, 15.84%, and 13.6%, respectively. The absence of comorbidities was associated with reduced energy levels at 12 months, and cervical histology was linked to worsening in CLAS2 and CLAS3. Additionally, a correlation was found between a total RT dose < 50 Gy and worsening fatigue (Table 1). Conclusion: In a cohort of GC patients treated with modern RT techniques, the onset of RT-related fatigue was reported in a minority. The total RT dose, absence of comorbidities, and cervical histology seem to be significant factors in the onset of fatigue

Keywords: Fatigue, Comorbidities, Gynaecological cancer

1993

Proffered Paper Target Volume and Tumour Regression Dynamics in Locally Advanced Cervical Cancer: report from the prospective EMBRACE II Study (NCT03617133) Johannes Knoth 1 , Stefan Ecker 1 , Ina Jürgenliemk-Schulz 2 , Petra S Kroon 2 , Jacob C Lindegaard 3 , Kjersti Bruheim 4 , Barbara Segedin 5 , Supriya Chopra 6 , Alina Sturdza 1 , Ericka Wiebe 7 , Henrike Westerveld 8,9 , Margit Valgma 10 , Laura Velema 11 , Cornelia G Verhoef 12 , Li T Tan 13 , Rachel Cooper 14 , Hanne F Mathiesen 15 , Pittaya Dankulchai 16 , Philip Y Wu 17 , Sophie Espenel 18 , Christian Kirisits 1 , Remi Nout 9 , Kari Tanderup 3 , Maximilian P Schmid 1 , Richard Pötter 1 1 Department of Radiation Oncology, Comprehensive Cancer Center, Medical University Vienna/General Hospital of Vienna, Vienna, Austria. 2 Department of Radiation Oncology, University Medical Centre Utrecht, Utrecht, Netherlands. 3 Department of Oncology, Aarhus University Hospital, Aarhus, Denmark. 4 Department of Oncology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway. 5 Department of Radiotherapy, Institute of