ESTRO 2025 - Abstract Book

S892

Clinical - Haematology

ESTRO 2025

Purpose/Objective: Uveal MALT lymphomas, a rare subtype of ocular lymphomas involving the choroid, ciliary body, or iris, are generally indolent. Their rarity complicates detailed demographic and epidemiological characterization. Radiotherapy (RT) has shown efficacy for MALT lymphomas in other sites, but its role in uveal cases remains underexplored. Material/Methods: This retrospective study analyzed uveal MALT lymphoma cases diagnosed between 2000 and 2021 from the SEER database across 17 registries. Patient demographics, clinical features, and treatment modalities were assessed. Descriptive statistics summarized data, and Kaplan-Meier analyses evaluated overall survival (OS) and cancer specific survival (CSS). Age-adjusted incidence rates were calculated based on the 2000 US Standard Population. Results: Among 22,246 extra-nodal MALT lymphomas, 27 were uveal MALT lymphomas, representing 0.12% of all cases. The age-adjusted incidence rate was 0.014 per 1,000,000 person-years. Uveal MALT lymphomas predominantly affected elderly patients, with a median diagnosis age range of 65-69 years, and over 40% of cases diagnosed in individuals older than 70 years. The male-to-female ratio was approximately 1.07. Most patients were Caucasian (74.07%), with Hispanic patients comprising the second largest group (18.5%).

Regarding treatment modalities, RT alone was the most common approach, administered to 15 patients (55.6%). Two patients (7.4%) received a combination of RT and chemotherapy, while 3 patients (11.1%) were treated solely with chemotherapy. Treatment data were unavailable for 7 patients.