ESTRO 2025 - Abstract Book

S893

Clinical - Haematology

ESTRO 2025

In the entire uveal MALT lymphoma cohort, with a median follow-up duration of 69 months, 10 patients (37.0%) died; causes of death included pulmonary disease (n = 4) and heart disease (n = 3). The five-year overall survival (OS) rate was 78.9% (95% confidence interval: 64.0–97.2), with a median OS of 149 months.Among the subgroup treated exclusively with RT (n = 15), 4 patients (26.7%) died during the median follow-up of 69 months, with causes of death including pulmonary disease (n = 2) and heart disease (n = 1). The five-year OS rate in this group was 92.3% (95% confidence interval: 78.9–100%), and the median OS was not reached. No relapses or lymphoma-related deaths were observed, resulting in a 100% five-year relapse-free survival (RFS) and cancer-specific survival (CSS). Conclusion: This study offers the most extensive analysis of uveal MALT lymphomas to date, confirming their rarity and favorable prognosis with effective treatment. RT was highly effective as a localized treatment, with potential for dose reduction to minimize morbidity. Further research is needed to refine treatment strategies and improve patient outcomes.

Keywords: Uveal MALT lymphoma; radiotherapy; epidemiology;

1128

Digital Poster Patients’ prioritizing of quality or length of life and travel distance of primary cutaneous lymphoma patients referred to radiotherapy

Khaled Elsayad, David Rene Steike, Isabel Falke, Christian Kandler, Hans Theodor Eich Department of Radiation Oncology, University Hospital Muenster, Muenster, Germany

Purpose/Objective: Patients with primary cutaneous lymphoma experience a reduced quality of life and often require referral to specialized centers. This analysis aims to assess patients' preferences regarding quality or length of life and travel distances to enhance the “shareddecision” process and their participation in future studies. Material/Methods: In our prospective cohort study, we recruited eighty-two patients with primary cutaneous lymphoma who were referred to the radiation oncology department for radiotherapy between September 2019 and August 2024. The main goal of this analysis is to investigate the priorities related to quality of life (QoL) and length of life (LoL) using the Quality-quantity Questionnaire. In addition, the participants filled out the Skindex-29 and the European Organization for the Research and Treatment of Cancer Quality of Life C30 (EORTC-QLQC30) questionnaires. Results: The median age of patients at the time of referral was 63 (range, 34 – 92) years. The majority of the patients had advanced-stage disease. 56 patients (68%) were diagnosed with mycosis fungoides (MF), 13 (16%) with Sézary syndrome (SS), and 13 (16%) with other types of primary cutaneous lymphoma. 31 patients (38%) placed greater importance on QoL compared to 21 patients (25%) who prioritized LoL. 30 patients (37%) rated QoL and LoL equally. The travel distance for patients with SS was notably longer (201 km) compared to the median travel distance of 114 km for MF patients and 65 km for non-MF-SS patients (p < 0.05). According to the multiple logistic regression analysis results, age (p = 0.019) and travel distance (p = 0.029) were significantly associated with a preference for QoL. Furthermore, we report the Skindex-29 and EORTC QLQ-C30 scores for every type of primary cutaneous lymphoma.

Conclusion: