ESTRO 2025 - Abstract Book

S896

Clinical - Haematology

ESTRO 2025

Keywords: bridging radiotherapy, CAR T Cell therapy 2022

Digital Poster Use of Unity MRI-linac for the treatment of non-Hodgkin lymphoma head and neck sites: preliminary experience from a prospective observational study. Andrea Emanuele Guerini 1 , Luigi Spiazzi 2 , Ludovica Pegurri 3 , Eneida Mataj 1 , Stefania Nici 2 , Stefano Riga 2 , Giorgio Facheris 1 , Paolo Borghetti 3 , Luca Triggiani 1 , Stefano Maria Magrini 1,4 , Michela Buglione di Monale 4 1 Radiation Oncology, Università degli Studi di Brescia, Brescia, Italy. 2 Medical Physics, Università degli Studi di Brescia, Brescia, Italy. 3 Radiation Oncology, ASST Spedali Civili di Brescia, Brescia, Italy. 4 Centro per lo Studio della Radioterapia guidata dalle Immagini e dai Biomarkers, Università degli Studi di Brescia, Brescia, Italy Purpose/Objective: Lymphomas are typically radiosensitive, causing the disease volume to decrease during the course of radiotherapy. The MR-linac offers superior soft tissue visualization and facilitates daily re-contouring of the gross tumor volume (GTV) and clinical target volume (CTV), making it a promising tool for lymphoma treatment. However, there is currently limited literature addressing its use in this context. Material/Methods: Clinical and dosimetric data were prospectively collected for the first eight patients with non-Hodgkin lymphoma (NHL) involving head and neck (H&N) regions, who were enrolled in a prospective observational study and treated using the Elekta Unity® MR-linac. These data were supplemented with relevant information from their medical records.

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