ESTRO Brachytherapy for Prostate Cancer 2018

Genetic influence on rectal morbidity?

• Genetic alterations in the ATM (Ataxia Teleangiectasia) gene are associated with rectal bleeding.

• 4/13 (31%) vs 1/23 (4%) if MPD <0,7cm 3 • 4/11 (36%) vs 1/21 (5%) if MPD 0,7-1,4cm 3

[ Cesaretti et al; Int J Radiat Oncol Biol Phys, 2007]