ESTRO Brachytherapy for Prostate Cancer 2018

Normal tissue effects and injury – Acute effects LDR prostate brachytherapy - urothelium

Acute effects

symptoms

outcome

management

urothelium Inflammation, oedema, hyperaemia,

irritative and obstructive – • Burning • urgency • frequency • nocturia

• Mostly self-limiting • Resolves spontaneously • Symptoms subside

Supportive Reassurance Pharmacological – • NSAID • Cortisone • cholinergic agonists • alpha-adrenergic blocking agents • anticholinergic agents • tricyclic antidepressants (TCAs) • sympathomimetic agents • Dr Stone’s urethral instillation formula Catheterization for retention

cellular loss with loss of epithelial integrity

gradually as radiation diminishes.

• urge incontinence • urinary retention • haematuria • spasmodic pain

• Typically takes 6-12 months • Do not generally convey risk of late complications