ESTRO Multidisciplinary Management of Breast Cancer 2017

Effect of Tamoxifen in DCIS ?

NSABP-24 trial, 2011: N =1799 Tam vs placebo (all RT) UK/ANZ trial, 2011: N = 1576 Tam vs placebo (half +/- RT)

Preventive effect on Ipsilateral DCIS

NSABP UK/ANZ

NSABP UK/ANZ

Preventive effect on contralateral DCIS

Staley et al, The Breast 2014