ESTRO Multidisciplinary Management of Breast Cancer 2017

Effect of Tamoxifen in DCIS?

NSABP-24 trial, 2011: N =1799 Tam vs placebo (all RT) UK/ANZ trial, 2011: N = 1576 Tam vs placebo (half +/- RT)

NSABP UK/ANZ

NO significant effect on ipsilateral invasive ca Tamoxifen works mainly preventive in patients with DCIS, but not therapeutic

NSABP UK/ANZ

Preventive effect on Contralateral invasive ca

Staley et al, The Breast 2014