ESTRO Multidisciplinary Management of Breast Cancer 2017

Why is there no relation between LR and margin width > 0 cm ?

Actual key-questions:

 What is the probability that tumorcells are left in situ? • Is this dependent on margin width ? YES !

 What is the estimated amount of tumorcells left in situ ? • Is this dependent on margin width ? NO ! Other factors more important, like age, grade and subtype:

• Chen et al 2014: simulation study & • Mihalcik et al 2017, analysis of LR, re-excision and residual disease, N = 1073