ESTRO PT 2018

Aim 1: Insight into Biologic Mechanisms  Specific Aim 1: To determine the early changes in multiple biomarkers in patients undergoing RT, and how these changes differ in proton versus photon therapy. – Hypothesis: Early increases in circulating biomarkers will differ according to RT; photon therapy will result in a more adverse biomarker profile.

Biologic Alteration

Biomarker

Inflammation

GDF-15, hsCRP

Microvascular Dysfunction

PlGF

Oxidative Stress

MPO, PON, Aryl

Myocyte Injury

TnT

Myocyte Stress

NT-proBNP

Fibrosis

Galectin-3