ESTRO PT 2018

Michael Goitein Radiation Oncology: A physicist’s-eye view. 2008. Springer Randomized Clinical Trials

A) Quantitative issues

1) Not “arguing against” randomized trials (as reduction any bias in patient selection):

2) Just discussing “difficulties…”: Measuring a combination of local control and (different) morbidities…

Proposal : compare using different “intensities” (eg two experimental arms) to be able to “interpolate” same likehood of morbidity as the control arm