ESTRO course on Image Guided Radiotherapy in Clinical Practice 2018

Uncertainty management: Conventional IMRT planning with margin

M = 2.5 Σ +0.7 σ

90% prob. of

CTV

PTV

D ≥ 95% D

prescribed

in CTV

Inverse optimization

OAR

Dose distribution

Objective functions Poisson cell kill, EUD, DVH points, ...

Witte et al, IJROBP 2007 Bohoslavsky et al IJROBP 2013