ESTRO course on Image Guided Radiotherapy in Clinical Practice 2018

Uncertainty management: Probabilistic biological IMRT planning without margin

no PTV margin!

Maximum  TCP  for given OAR  NTCP 

CTV

Inverse optimization

OAR

Dose distribution

Objective functions with simulated errors  TCP  ,  NTCP 

Σ , σ

Witte et al, IJROBP 2007 Bohoslavsky et al, IJROBP 2013