ESTRO meets Asia 2024 - Abstract Book

S178

Interdisciplinary – Head & neck

ESTRO meets Asia 2024

Unlike published phase II/III trials testing adding immunotherapy to radical HNC treatment, our results looks more promising regarding CR of otherwise incurable disease. Our patients are younger, more Asian and with more oral cavity cancers. Toxicity profile looks similar to documented in other trials but the severity of neutropenia needs more meticulous management and possible consideration of G-CSF prophylaxis in some patient. Expansion of the study group during this meeting to include more west Asian countries would be very valuable.

Keywords: Head and neck cancer, Immunotherapy, radical

References:

https://clinicaltrials.gov/study/NCT03532737 accessed 24-1-2024 https://clinicaltrials.gov/study/NCT03040999?tab=results accessed 10-1-2024 Machiels P et al. Annal Oncol 33, suppl 7, S1399 (2022) Lee N, et al. The Lancet Oncol, 22 (2021): 450-462 Tao Y, et al. European Journal of Cancer 141 (2020): 21-29 Gillison M, et al. Inter J of Rad Oncol Bio Phys. 115, 4 (2023): 847-860

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Digital Poster

immunological profiling of radiation-induced oral mucositis in a murine model

Hao Yu 1 , Kaikai Ding 1 , Jianxiong Ji 2 , Guorong Yao 1 , Kairui Xu 3 , Senxiang Yan 1

1 Department of Radiation Oncology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. 2 Department of Neurosurgery, the Second Affiliated Hospital of Zhejiang University School of Medicine, Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hanzghou, China. 3 Department of Stomatology, Hangzhou Linping Hospital of Traditional Chinese Medicine, Hangzhou, China

Purpose/Objective:

Radiation-Induced Oral Mucositis (RIOM) is a common toxic side effect observed in patients undergoing radiotherapy for head and neck tumors. To date, effective therapeutic interventions for this complication remain elusive. This study aims to elucidate the pathogenic mechanisms of RIOM from an immunological microenvironment perspective, providing a scientific foundation for the future development of more efficacious treatment strategies.

Material/Methods:

Female C57BL/6 mice aged 8-10 weeks were randomly assigned to either the control or irradiation group. Mice were anesthetized and received 8 Gy * 3 fractionated irradiation to the head and neck. Monitoring of body weight changes was conducted to determine the onset of RIOM. Euthanasia was performed upon the manifestation of RIOM symptoms, and tongue mucosa samples were extracted for mass cytometry analysis to comprehensively assess immune cell infiltration.

Results: