ESTRO meets Asia 2024 - Abstract Book

S184

Interdisciplinary – Head & neck

ESTRO meets Asia 2024

Material/Methods:

Demographic, clinical and pathological data of 113 patients with oral cavity squamous cell carcinoma who underwent curative surgical treatment from January 2022 to September 2023 at our Institute was recorded. Patients having inadequate pathological reporting were excluded. A statistical analysis was performed on the collected data using IBM SPSS Statistics software version 23.

Results:

Out of 113 patients, 32(28.31%) had LVI positivity. Out of these 32 patients, 18(56.25%) had a T size of >3 cm (p = 0.029), 27(84.37%) had nodal positivity with more than 2/3 rd of them having N2-N3 nodal stage (p < 0.01), 18(56.25%) had perineural invasion (p = 0.017) and 30(93.75%) patients had a DOI of >1 cm (p < 0.01). 25 of the total 113 patients had locoregional and/or distal recurrence upon follow up out of which 15(60%) were LVI positive with a p value of 0.01.

Conclusion:

In oral cavity cancers, there is a positive association of LVI with various tumor-node related prognostic factors and the clinical outcomes. Hence, it can be considered as an independent prognostic factor in guiding patient management in oral cavity cancers.

Keywords: Lymphovascular Invasion(LVI), Prognostic factor

References:

1. Adel, Mohamad MD, MSc; Kao, Huang-Kai MD; Hsu, Cheng-Lung MD, PhD; Huang, Jung-Ju MD; Lee, Li-Yu MD; Huang, Yenlin MD, PhD; Browne, Timothy MD; Tsang, Ngan-Ming MD, DSc; Chang, Yu-Liang DDS, PhD; Chang, Kai Ping MD, PhD. Evaluation of Lymphatic and Vascular Invasion in Relation to Clinicopathological Factors and Treatment Outcome in Oral Cavity Squamous Cell Carcinoma. Medicine 94(43):p e1510, October 2015 2. Huang Q, Huang Y, Chen C, Zhang Y, Zhou J, Xie C, Lu M, Xiong Y, Fang D, Yang Y, Hu W, Zheng F, Zheng C. Prognostic impact of lymphovascular and perineural invasion in squamous cell carcinoma of the tongue. Sci Rep. 2023 Mar 7;13(1):3828

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Radiotherapy with or without weekly cisplatin for elderly patients with head and neck cancer

Yumi Kokubo 1 , Shinya Hiraoka 2 , Yo Kishimoto 3 , Shogo Shinohara 4 , Ryota Nakashima 2 , Aya Nakajima 2 , Michio Yoshimura 2 , Chiaki Suzuki 3 , Keigo Honda 3 , Peter J. K. Tokuda 1 , Ryo Ashida 1 , Takamasa Mitsuyoshi 1 , Toshiyuki Imagumbai 1 , Tetsuhiko Michida 4 , Masahiro Kikuchi 4 , Masaki Kokubo 1 , Koichi Omori 3 , Takashi Mizowaki 2 1 Department of Radiation Oncology, Kobe City Medical Center General Hospital, Kobe, Japan. 2 Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan. 3 Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. 4 Department of Otolaryngology-Head and Neck Surgery, Kobe City Medical Center General Hospital, Kobe, Japan