ESTRO meets Asia 2024 - Abstract Book

S233

Interdisciplinary – Other

ESTRO meets Asia 2024

[3] “DirectDensity™ Technical principles and implications for radiotherapy”. White Paper, Siemens Healthineers, 2016.

118

Proffered Paper

efficacy of postoperative radiation therapy on local control rates in keloid treatment

Bongkotrat Enchai, Chuleeporn Jiarpinitnun, Supakiet Piasanthia, Nattinee Wattakiyanon

Division of Radiation Oncology, Department of Diagnostic and Therapeutic Radiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Purpose/Objective:

Treating keloids can be challenging due to their high recurrence rates. The efficacy of postoperative radiation therapy (RT) in improving local control (LC) have been investigated. The previous studies reported mixed outcomes. Identifying the patient who would derive the greatest benefit from RT remains a significant question. This study aimed to evaluate the LC rates of keloids treated with surgery followed by RT, to identify recurrence risk factors, and to assess the adverse effects of RT.

Material/Methods:

We included patients clinically diagnosed with keloids who underwent surgery and followed by postoperative RT. The patients had a follow-up period of at least 6 months between January 2010 and December 2021. The primary objective was to evaluate the LC rate of keloids after postoperative RT. Secondary objectives included identifying risk factors for keloid recurrence and assessing adverse effects from radiation therapy.

Results:

We examined 98 keloid lesions from 69 patients who underwent surgery followed by postoperative RT. The median follow-up was 23.5 months (range 6-105). Our findings showed that the 2-year LC rate was 54.5%. A history of recurrence prior to this treatment was a statistically significant risk factor for local recurrence. Patients with a previous history of recurrence in the treated keloid had an LC of 18% when compared to 95% in those with no prior history. In the multivariable analysis, the hazard ratio of the previous history of recurrence on LC was 30.87 (95% CI 7.34-129.85; p <0.001). Skin hyperpigmentation was a common adverse effect with incidence of 70%.

Conclusion:

Postoperative RT is an effective treatment for keloid patients, providing reasonable local control for those with no prior recurrence history. However, further prospective studies are needed for patients who have experienced recurrence to determine the most appropriate treatment modality for achieving local control.

Keywords: Keloid, Postoperative radiotherapy, Local control