ESTRO meets Asia 2024 - Abstract Book

S235

Interdisciplinary – Other

ESTRO meets Asia 2024

18. Hwang NH, Chang JH, Lee NK, Yang KS. Effect of the biologically effective dose of electron beam radiation therapy on recurrence rate after keloid excision: A meta-analysis. Radiother Oncol. 2022 Aug;173:146–53.

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Interpretating Results from Intermittent Radiation Exposure from in-vivo study, where are we?

Marhendra Satria Utama 1 , Iwan Setiawan 2 , Hanna Goenawan 2

1 Radiation Oncology sub-division, Department of Radiology, Hasan Sadikin General Hospital /Universitas Padjadjaran, Bandung, Indonesia. 2 Physiology Division, Department of Biomedical Science, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia

Purpose/Objective:

this study aims to evaluate the potential effects of intermittent radiation and explore the effect of the fraction and time lag during the use of intermittent radiation.

Material/Methods:

This study using a systematic review followed Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. Literature searches were performed by subjects in a number of databases including PubMed, Scopus, ProQuest, Wiley, and Cochrane

Results:

A total of 2857 studies were found due to thorough initial searches. After eliminating 1221 duplicates, the authors screened titles and abstracts. A total of eight studies were included in the analysis, which was conducted using qualitative methods. This study is the first systematic review study to assess radiotherapy in rats. In this study, most of the samples used were female mice, with the most types of cancer being EMT6 and SCCVII cells. The use of radiotherapy is still a challenging thing for physicians in terms of clinics. Given that there is still much to be improved, the effectiveness of its use is expected.

Conclusion:

T he effectiveness of using radiotherapy depends on the fraction, dose, and time interval. One fraction with a high dose can significantly impact TGT and survival time. However, this cannot be concluded because it is still not known what effect it can have on humans with the same treatment on rats in this study, so conducting clinical trials on humans is necessary.

Keywords: Hypoxic fraction, In-vivo study, Radiotherapy

References: