ESTRO meets Asia 2024 - Abstract Book

S84

Interdisciplinary – Breast

ESTRO meets Asia

This is a retrospective study of localised, resected malignant PT patients who had received adjuvant RT up to at least 60 Gy between 2013 and 2023 at our centre. Kaplan-Meier and Cox regression methods were used for statistical analyses.

Results:

A total of 35 patients were identified with a median age of 49 years (range 31 – 69). Most patients were premenopausal (54.3%) with predominant race was Malay (71.4%). The median pathological tumour size was 13.5 cm (range 3 – 27 cm). Majority had underwent mastectomy (85.7%) and 14.3% had breast conserving surgery. 25.7% had axillary clearance while 8.6% had axillary sampling, in which all the nodes were pathologically negative. Surgical margins were negative in 20%, close in 68.6% and positive in 11.4%. The median follow-up was 48.4 months (range 7.0 – 146.3). LR occurred in 1 patient (2.9%) at 73 months. DM occurred in 6 patients (17.2%) at the mean time of 38.2 months (range 7.0 – 96). Lung was the most common site of metastasis followed by liver and bone. The 5-year and 10-year OS were 80% and 74% respectively. Age, tumour size, type of surgery and surgical margin were not associated with LR, DM or OS. The median OS was not reached.

Conclusion:

Adjuvant radiotherapy is an appropriate treatment in achieving disease control for aggressive malignant PT. Further study is needed to elucidate the clinicopathological and treatment factors associated with recurrence and survival outcomes.

Keywords: malignant, phyllodes, radiotherapy

References:

Chao X, Chen K, Zeng J, Bi Z, Guo M, Chen Y, Yao Y, Wu W, Liang S, Nie Y. Adjuvant radiotherapy and chemotherapy for patients with breast phyllodes tumors: a systematic review and meta-analysis. BMC Cancer. 2019 Apr 23;19(1):372. doi: 10.1186/s12885-019-5585-5. PMID: 31014268; PMCID: PMC6480723.

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Digital Poster

From 15 to 5, adapting ultra hypo fractionated radiotherapy in Bangladesh: A single center study

Aditi Paul Chowdhury 1 , M.Juel Khondakar 1 , Nowshin Taslima Hossain 1 , Jannatul Ferdause 1 , Sura Jukrup Momtahena 1 , Rubama Karim 1 , Qazi Mushtaq Hussain 2 1 Radiation Oncology, Ahsania Mission Cancer and General Hospital, Dhaka, Bangladesh. 2 Radiation Oncology, Labaid Cancer Hospital and Superspeciality Center, Dhaka, Bangladesh

Purpose/Objective:

GLOBOCAN data suggests that Breast cancer is the most commonly diagnosed cancer among Bangladeshi females. Ahsania Mission Cancer Hospital registry data says about 16.6 % breast cancer patients came to this hospital with breast cancer diagnosis last year, which is highest among all cancers. Bangladesh is currently dealing with a huge number of breast cancer patients with very limited radiation facility. Moderate hypo fractionation for breast radiotherapy is practised all over our country. As Ultra Hypofractionated Radiotherapy (UHFRT) for early breast cancer is a well-established fractionation in recent world. This study aims to adapt this protocol at our center.