ESTRO 37 Abstract book

ESTRO 37

S617

Results Total Doses ranged between 15 – 50 Gy (fractionation 3 – 20Gy/fraction). Most frequent Schedule: 45 Gy, 15 Gy/fraction. Most frequent global toxicity (acute/chronic) was grade 1: 77%. No toxicity higher than grade 2 was achieved. 1.PTV VOLUME : Range: 10.72-232cc. Mean: 52.12cc; median: 41.36. PTV groups: - <50cc: 33 (62%). - 50-100cc: 15 (28%). - >100cc: 5 (10%). CHRONIC TOXICITY (>12months) AND PTV: 23 cases. Most frequent toxicity: grade 1 in PTV <50 group: 11 cases. Highest toxicity (grade 2) only observed in one case with PTV <50. (TABLE 1) 2. - MEAN DOSE : Three groups of MD to healthy lung (49 cases):

developed, probably due to the small size of the lesions being treated.

PO-1095 Tolerance and toxicity of treatment in patients undergoing radiotherapy associated with hyperthermia A. Nowak 1 1 Greater Poland Cancer Centre, Department of Radiotherapy, Poznań, Poland Purpose or Objective Due to continuous increase of tumour incidence, new treatments are still being sought. Beyond radiotherapy and chemotherapy, there is growing interest in hyperthermia. This is a non-invasive method that causes only a rise in temperature inside the tumour. The aim of hyperthermia is to support the main treatments and it should not be used separately. Material and Methods Analysed population consists of 20 patients diagnosed with cervical cancer. The research was conducted on the basis of observation during therapy and a short survey. The patients were treated according to the following pattern : hyperthermia (1-2 a week), maximum 1 hour break, radiotherapy. Hyperthermia was performed on Celsius 42+, which produces electromagnetic waves in the 13.56 MHz range. The intensity during treatment was increased in accordance with the manufacturer's recommendations. The survey consisted of questions about the occurrence of side effects and evaluation of treatment. The type and frequency of symptoms, the number of treatments for tolerance, the weight influence on the occurrence of side efects, and thereby the toxicity of treatment were analysed. Results An analysis of a given population shows that patients indicate 4 major problems such as stinging of pubic bone, stinging of navel, reddening of the skin and numbing of buttocks. It has been observed that there is a correlation between the number of sessions and the occurrence of side effects that cause discomfort among patients. In 3 patients, side effects appeared after 1 st or 2 nd session, in 9 patients during 3 rd or 4 th session and in 6 patients during or after 5 th session. During BMI analysis it can be observed that in patients with BMI<25 there is always stinging of navel and the reddening of skin whereas in patients with BMI >18,5 it is certain to observe stinging of pubic bone. Taking into account the tolerance resulting from the number of breaks, it turns out that 65% of patients showed very good tolerance, 25% good and 10% bad, as shown in Figure 1.2. Obese patients show less resistance and therefore required more pauses during treatment. 15 patients rated hyperthermia as comfortable treatment, 3 patients as neutral and 2 patients as uncomfortable.

- <10 Gy: 45 (92%). - 10 – 20 Gy: 3 (6%). - > 20 Gy: 1 (2%).

CHRONIC TOXICITY : 22 cases. Most frequent toxicity was grade 1 in the MD <10Gy group. There was no high toxicity (≥ 2) in groups with MD <10Gy ( TABLE 2)

PTV VOLUME (cc)

GR

GRADE 0 TOX

GR

GR 3

1

2

11

5

<50cc

1

17

(29%)

(65%)

(6%)

(73%)

4

50-100cc

0

4

(100%)

0

(18%)

2

100cc

0

(100%)

0

2 (9%)

TABLE 1. PTV AND TOXICITY

MEAN

DOSE

GRADE 0 TOX

(Gy)

GR 1

TOTAL

GR 2

16

1

< 10

4 (19%)

21 (95%)

(76%)

(5%)

1

10-20

0

1 (5%)

(100%)

0

> 20

0

0

0

0

TABLE MEAN

2.

DOSE AND TOXICITY

Conclusion The overall pulmonary toxicity in treatment of lesions with SBRT is low and tolerable. Most treated lesions reach a small volume of treatment and the mean dose received by the healthy lung is low. Neither the PTV nor the MD to healthy lung appears to have a marked influence on the degree of toxicity

Made with FlippingBook - Online magazine maker