ESTRO 37 Abstract book

S895

ESTRO 37

secondary bleeding who were treated with superficial radiotherapy for haemostatic purposes Material and Methods For a period from May 2016 to August 2017, 6 patients with locally advanced breast cancer who did not respond to systemic treatment or due to the disease or comorbidities associated were not candidates for that, who presented tumour growth with secondary bleeding and they were not subsidiaries of surgery. Superficial radiotherapy were administrated by a low energy X-Ray machine, with a total dose of 50 - 60Gy, divided in 1-2 fractions per week. The haemostatic effect was value at the end of treatment. Results The average age was 73 years, most patients presented a grade 2 functional status (ECOG2). At the end of treatment, was objected a decrease of > o = 25% in tumor size and absence of bleeding was observed. Conclusion Surface radiotherapy is a treatment modality that should be taken into account in patients with breast cancer who present bleeding as a consequence of local tumor growth, given that this is a treatment comfortable for the patient, non invasive and increases the quality of patient’s life. Fractionated Stereotactic Spine Radiosurgery for Spinal Metastases S. Lai 1,2 , Y.F. Chen 3 , F.R. Xian 4 , F.M. Hsu 1,5 1 National Taiwan University Hospital and College of Medicine, Division of Radiation oncology- Department of Oncology, Taipei, Taiwan 2 National Taiwan University, Institute of Biomedical Engineering- College of Medicine and College of Engineering, Taipei, Taiwan 3 National Taiwan University Hospital and College of Medicine, Department of Radiology, Taipei, Taiwan 4 National Taiwan University Hospital and College of Medicine, Department of Surgery, Taipei, Taiwan 5 National Taiwan University, Graduate Institute of Oncology- College of Medicine, Taipei, Taiwan Purpose or Objective Spinal stereotactic radiosurgery (SSRS) is commonly being adopted in patients with spinal metastasis recently as it could provide dose escalation for durable tumor control with sparing of nearby organs at risk. However, there is no solid evidence about the optimal treatment schedule and no comprehensive understanding of the adverse events. In this study, we sought to compare two most widely used SSRS schemes (single fraction versus three fractions) in patients with spinal metastasis who did not previously undergo radiation treatment at the site of the SSRS and tried to evaluate the toxicity profile as well as predictive factors regarding outcomes and the risk of complications after SSRS. Material and Methods Patients were prospectively enrolled in the single- institution randomized study. Dose regimen was single- fraction of 16-Gy versus 3-fraction of 24-Gy. The primary objective is the rate of 4-month grade 3 or higher adverse events definitely, probably or possibly related to treatment. Spinal Instability Neoplastic Scoring (SINS) system were incorporated into the protocol to predict the adverse event of each anticipant. Local control was determined by serial post-treatment image scans. Results Between 2015/11 and 2017/5, SSRS was performed in 23 sites on 20 patients (including 18 lung cancer patients, 1 EP-1662 Single Versus Multiple

breast cancer patient and 1 prostate cancer patient). The median age was 58 years (range 45 - 79). The median KPS was 80 (range 70-100). Of the 23 sites, 20 were single level targets. Thoracic spine (n = 15) and lumbar spine (n=7) were the most common sites. Single fraction radiosurgery was delivered in 11 patients while 3-fraction regimen was delivered in 9 patients. Median follow-up was 11.03 months (95% confidence interval: 8.26-13.81 months). At 4 months, no patient experienced any grade 3-5 toxicity. Pain flare was not reported in the irradiated sites. There was no evidence of vertebral body fracture related to the SSRS in any patient in the treated area. Conclusion Both single fraction and three fraction SSRS could provide durable and favorable pain and local control for patients who have previously unirradiated spinal metastasis with mild/tolerable toxicity profile. EP-1663 Quality of Life study in elderly breast cancer survivors. Differences among axillary surgery groups J.I. Arraras 1 , A. Manterola 2 , J.J. Illarramendi 3 , G. Asin 2 , E. Salgado 3 , B. Ibañez 4 , A. Galbete 4 , M.A. Dominguez 2 1 Complejo Hospitalario de Navarra, Radiotherapeutic Oncology, , Spain 2 Complejo Hospitalario de Navarra, Radiotherapeutic Oncology, Pamplona, Spain 3 Complejo Hospitalario de Navarra, Medical Oncology, Pamplona, Spain 4 Navarrabiomed- Departamento de Salud-UPNA – REDISSEC, Methodology Unit, Pamplona, Spain Purpose or Objective Quality of Life (QL) is considered a key aim in elderly patients. There is an interest in studying QL in elderly breast cancer survivors, and also the differences among axillary surgery groups after a long follow-up period, The aim is to assess the evolution of QL in elderly breast cancer survivors along three years of follow-up since the start of the treatment, and to compare the QL among different axillary surgery groups. Material and Methods 138 out 173 patients ≥ 65 years in early disease stages who started treatment, completed the EORTC QLQ-C30 and QLQ-BR23, and the Interview for Deterioration in Daily Living Activities in Dementia (IDDD) questionnaires 3 years after radiotherapy end. These patients also filled in these questionnaires before the start of irradiation. Linear mixed effect models were used to evaluate longitudinal changes in QL, and whether these changes differed among axillary surgery groups (axillary node dissection, sentinel node biopsy and no surgery). Differences among axillary surgery groups were also studied three years after the end of the treatment (Anova, Kruskal-Wallis, Chi Square). Results QL scores three years after the end of the treatment were high (>70/100 points) in most QL areas, with moderate limitations (>30 points) in sexual functioning and enjoyment. Compared with the pre-treatment assessment, an improvement of QL scores along the follow-up was observed for four areas: pain, nausea and vomiting, financial impact and breast symptoms. There was no worsening in any QL area. There were no significant differences in the changes between the pre-treatment and the follow up Electronic Poster: Clinical track: Elderly