ESTRO 37 Abstract book

S901

ESTRO 37

adopt use of financial toxicity screening tools. Post- treatment patient surveys were used to investigate covariates of treatment induced financial risk. Results Of the 210 radiation oncologists that completed our survey, 53% reported being “very concerned” with treatment related costs negatively affecting their patients, and 80% believed that a financial toxicity screening tool would be useful in practice. Analysis of patient surveys using logistic regression found age, money owed, and worries about making the copayment as the most important variables in predicting risk of financial toxicity. Thirty-four (22%) patients experienced financial toxicity related to treatment. Our screening model had a very good predictive performance in these data (c- statistic = 0.85).

every 3 years serves as the screening test. The aim of the study was to analyze an impact of the screening program on the incidence and survival rates of women residing in Lower Silesia Province (Poland). Material and Methods 3298 cases of cervical cancer diagnosed in Lower Silesia Province recorded in 2005-2014 and 5-year OS of 3,586 patients treated in the years 2000-2010 were analyzed, respectively. Epidemiological data were obtained from the Lower Silesian Cancer Registry in Wroclaw. In order to exclude the effect of age on the 5-year OS relative survival values based on life expectancy tables were calculated. Statistical calculations were performed in Microsoft Excel using the Chi-square test with Yates correction. Results In 2005-2014, 2563 new cases of invasive cervical cancer (C53) and 735 new cases of preinvasive cancer (D06) were registered. In the analyzed period, incidence of C53 decreased by 6 cases per year and incidence of D06 increased by 4 cases per year. The observed changes were especially related to the screening population.

Odds Ratio

Effect

95% CI

p

Age 20-60 years old vs 71+ years old Age 61-70 years old vs 71+ years old Money owed $5K-$25K vs. Blank or <$5K Money owed $25K-$45K vs. Blank or <$5K Money owed $45K or more vs. Blank or <$5K Worried about copay?: Very vs Not Worried about copay?: Somewhat vs Not

0.96

-

5.72

0.06

34.09

0.40

-

2.42

0.34

14.79

Tab. 1. 5-year relative OS Lower Silesian cervical cancer patients in 2000-2010.

1.93

-

7.57

<.01

29.76

1.04

-

5.21

0.04

26.02

0.45

-

1.98

0.36

8.69

2.01

-

20.50

<.01

21.09

4.37

-

6.51

<.01

96.19

Conclusion Financial toxicity is an important measure for patients and providers that is experienced in approximately one quarter of patients. A financial toxicity screening tool is feasible and can predict patients at high risk of developing financial toxicity due to treatment. Further studies to improve models to predict financial toxicity and how financial toxicity is related to patient outcomes and quality of life are warranted. EP-1676 Impact of Population-Based Cervical Cancer Prevention and Early Detection Program in Lower Silesia D. Zielecka-Dębska 1 , D. Blaszczyk 2 , J. Blaszczyk 3 , K. Lichon 1 , A. Maciejczyk 4 , J. Szelachowska 5 , R. Matkowski 1 1 Lower Silesian Oncology Center, Department of Oncology, Wrocław, Poland 2 Lower Silesian Oncology Center, Wojewodzki Osrodek Koordynojacy Progmamy Profilaktyczne, Wrocław, Poland 3 Lower Silesian Oncology Center, Zaklad Epidemiologii i Dolnoslaski Rejestr Nowotworow, Wrocław, Poland 4 Lower Silesian Oncology Center, Clinic of Radiation Oncology, Wrocław, Poland 5 Lower Silesian Oncology Center, Gynaecological Oncology Clinic, Wrocław, Poland Purpose or Objective Poland is ranked among the countries with medium cervical cancer incidence (around 3000-3500 / year) and with a low 5-year overall survival rate (OS) - 55.2%. In 2006 Poland introduced the Population-Based Cervical Cancer Prevention and Early Detection Program for women aged 25-59, in which a cytology test performed

In addition, the beneficial effect of the program was a constant increase in the percentage of 5-year relative OS among women with cervical cancer (C53 and D06). This percentage increased from 55.1% in 2000-2004 to 60.5% in 2005-2009, and in 2010 it reached 70.8% (Tab 1) (p <0.00001). Table 2. The number of cases of C53 and D06 in the Lower Silesian Province in 2005-2014 with the division into age groups.

Conclusion Despite the small screening test population coverage (21%) in the Lower Silesian Province (this low coverage rate is similar in other parts of Poland), the decline in incidence of C53 and the increase in D06 were observed (Tab. 2). In women covered by screening in years 2006 – 2014, D06 accounted for 20-43% of all cases of cervical cancer, while in women above 60 years, only 3-11% (P <0.0001). In the study group we observed a steady increase in the percentage of 5-year OS. Among patients