Haematology 2018

RT and anti-PD1 therapy results in changes in TIL population with increase in CD8 T cells CD8 CD4

A=irradiated, B=shielded

4 0

1 5

**

0 F re q u e n c y o f C D 8 + ce lls 1 0 2 0 3 0

0 F re q u e n c y o f C D 4 + ce lls 5 1 0

*

*

*

*

a s a p e rc e n ta g e o f C D 4 5 +

a s a p e rc e n ta g e o f C D 4 5 +

7 2 h r

7 2 h r

7 2 h r

7 2 h r

7 2 h r

7 2 h r

7 2 h r

7 2 h r

2 4 h r s

2 4 h r s

2 4 h r s

2 4 h r s

7 d a y s

7 d a y s

7 d a y s

7 d a y s

2 4 h r s

2 4 h r s

2 4 h r s

2 4 h r s

7 d a y s

7 d a y s

7 d a y s

7 d a y s

A

B

A

B

A

B

A

B

N o n T re a te d

5 x 2 G y R T +  P D -1 m A b

N o n T re a te d

5 x 2 G y R T +  P D -1 m A b

• RT and αPD-1 mAb leads to reduction in CD8 + T-cells (but not CD4 + T-cells) infiltrating the tumor (when compared to out-of field lesions at 24 hours). • Reduction in CD8 + T-cells acute, by day 7 both the irradiated and out-of-field tumors had significantly greater numbers of CD8 + T-cells