Haematology 2018

Efficacy of first-line treatment for FL

Estimating the need for treatment in FL

Considering 100 patients treated…

Advanced, asymptomatic

Symptomatic, requiring systemic treatment

Localised

Disease status at diagnosis

69% overall 1

6% 1

18% 1

IFRT

Watch and wait

19% ≥10 years without treatment 2

81% progress 2

15% overall 1,2

(~3% overall)

~50% ≥10 years without relapse 3

~50% progress 3

3% overall 1,3

(~3% overall)

>85% of patients eventually require systemic treatment

All figures are estimates based on: 1. Friedberg J, et al. J Clin Oncol 2009; 27:1202–1208; 2. Ardeshna KM, et al. Lancet 2003; 362:516–522; 3. Yahalm J. Curr Treat Options Oncol 2014; 15:262–268.

FL, follicular lymphoma; IFRT, involved-field radiotherapy