Haematology 2018

No survival benefit with immediate chemotherapy treatment vs watch and wait in patients with asymptomatic FL

Overall survival

Advanced stage but clinically non-aggressive (BNLI) defined by absence of:

100

Observation (n = 151) Chlorambucil (n = 158)

80

Pruritis or B symptoms Rapid progression in last 3 months

60

Life-threatening organ involvement

40

(%)

20

Cytopenias secondary to bone marrow involvement

Cumulative survival 0

Bone lesions

Time (years) 0 4 8 12 16 20 24

Renal infiltration Macroscopic liver involvement

Ardeshna KM, et al. Lancet 2003; 362:516–522.