Haematology 2018

INV-assessed PFS in the FL population

Kaplan-Meier plot of INV-assessed PFS by treatment arm (FL)

1.0

G-B, n=164

B, n=171

0.8

Pts with event, n (%) Median PFS (95% CI), mo HR (95% CI), p-value*

93 (56.7)

125 (73.1)

0.6

25.3 (17.4, 36.0)

14.0 (11.3, 15.3)

0.4

Probability

0.52 (0.39, 0.69), p<0.0001

B (n=171) G-B (n=164) Censored

0.2

+

0

Median follow-up (FL): 31.2 months (vs 21.1 months in primary analysis)

6 0

Time (months) 12 18 24 30 36 42 48

54

60

No. of patients at risk B G-B 141 138 171 164

0 0

84 107

45 86

32 67

18 49

15 40

9 26

4 15

0 4

*Stratified analysis; stratification factors: prior therapies, refractory type, geographical region

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