Hematological Malignancies

PCNSL Baseline Evaluation

• Pathologic Evaluation – Centralized confirmation of pathology with immunopathology when possible • Clinical Evaluation – Complete medical, neurological, cognitive examination – Determination of prognostic factors (age, PS) • Laboratory Evaluation – HIV, lactate dehyrogenase, creatinine clearance • Extent of Disease Evaluation – Brain- Contrast-enhanced cranial MRI – CSF- Cytology, flow cytometry, IgH PCR – Eye- Slit lamp evaluation – Body- CT of chest/abdomen/pelvis; BM biopsy + aspirate. Consider testicular US in older men