Hematological Malignancies

The debated role of RT consolidation

• A brief (forgotten) history of WBRT alone • The breakthrough for cure with MTX followed by WBRT

• The great concern of post-MTX radiation-related neurotoxicity • Efforts to match the results of combined modality with higher dose chemotherapy alone and effective salvage • The controversial phase III study • High-dose chemotherapy with autologous stem cell transplantation • An alternative combined modality with low-dose RT and rare toxicity