Hematological Malignancies

Breast cancer following HL a Dutch case-control study

Radiation dose in Gy (median)

Cases

Controls

OR†

95%CI

<4 (3.6)

9

47 39 44 45

1.0* 1.11 4.20 5.16 OR†

Ref

4-24 (15.5)

10 14 15

0.32-3.85 0.99-17.8 1.27-21.0

24-38.5 (30.2) ≥ 38.5 (40.7)

Overall treatment

Cases

Controls

95%CI

RT only RT+CT

30 18

68

1.0

Ref

104

0.45

0.22-0.91

* P trend <0.001; † adjusted for RT dose ovary and CT

• Highest risks in youngest patients • Induction period: 10-15 years

van Leeuwen JNCI 2003: 95;971