Hematological Malignancies

Risk of breast cancer after RT for HL, by duration of ovarian function after RT

6 Hazard ratio

5.3 [2.9-9.9]

5

4

3

2

Reference

1

0.3 [0.2-0.6]

0

< 10 yrs

10-20 yrs

>=20 yrs

years of intact ovarian function after RT

Ovarian hormones crucial in radiation-induced breast carcinogenesis De Bruin et al, JCO 2009