ICHNO-ECHNO 2022 - Abstract Book

S107

ICHNO-ECHNO 2022

Purpose or Objective Head and neck cancer (HNC) comprises a group of fast-growing tumors in fundamental for swallowing, speaking, and socializing. The impact of HNC can be measured through patient-reported outcome measures (PROMs). As current PROMs had methodologic and content deficiencies with an underrepresentation of the changes in appearance, the FACE-Q HNC Module was developed. In the Netherlands, the EORTC-QLQ-H&N35 is the most used PROM for HNC patients. We investigated the content and known groups validity of the FACE-Q HNC module and its relation to the EORTC-QLQ-H&N35 scores. Materials and Methods A cross-sectional multicenter PROM study in five Dutch HNC centers. We included patients diagnosed with primary HNC or curatively treated for it within the past three years. Patients were offered the PROMs between diagnosis, up to three years after completion of treatment. The validity of the HNC module, translated in Dutch, was assessed according to the COSMIN tool. FACE-Q scores were calculated using the Rasch measurement theory analysis. Results Despite delay in study setup and the drop in HNC incidence during the COVID-19-pandemic, the total number of inclusions is expected to reach 700 in January 2022. Up to October 2021, response rates are 81% (406 responses out of 501 inclusions). Ten percent were included pre-treatment, and the latter was three months (12%) up to two to three years (31%) post- treatment. Patient-, tumor- (subsite, stage) and primary treatment characteristics were collected, according to the national Dutch Head and Neck Audit. Especially the FACE-Q rash scores on the subscale appearance distress differed between the centers (Figure 1). Known groups' validity will be assessed based on predetermined subgroups: pre-treatment or follow-up, treatment modality, and intensity. Convergent validity is checked with the EORTC-QLQ-H&N35. Data distribution is studied using REDCap©.

Figure 1. Distribution FACE-Q scores on appearance distress based on the rash measurement theory analysis (0 – 100, with 0 as the most distress and 100 as no distress). The scores per patient, with a overall mean of 78, are shown for primary head and neck cancer patients across the entire cohort (A), within the head and neck oncologic center in urban to suburban region (B) and a preferred partner in a mostly rural area (C). Conclusion Study inclusions and PROM response rates remain high despite COVID-19-related challenges. The impact on appearance seems to differ across this cohort and could be of additional value to evaluate patients’ quality of life. To what extent differences in FACE-Q scores relate to mentioned subgroups, and whether the FACE-Q scores are similar to that of corresponding EORTC domains will be answered during the ICHNO-ECHNO 2022.

Poster: Salivary gland, skull base, skin and thyroid cancers

PO-0170 Survival outcomes of parotid carcinoma treated with surgery and radiotherapy or radiotherapy alone

M.S. Iqbal 1 , F. Jamil 2 , J. Kovarik 2 , M. Cunnell 3 , C. Kelly 1 , S. Saha 4 , R. Patil 1 , J. O'Hara 5 , D. Hamilton 5 , H. Fox 5 , L. Warner 5 , O. Ahmed 6 , A. Waton 1 , D. Saleh 6 1 Northern Centre for Cancer Care, Clinical Oncology, Newcastle upon Tyne, United Kingdom; 2 Northern Centre for Cancer Care , Clinical Oncology, Newcastle upon Tyne, United Kingdom; 3 Northern Centre for Cancer Care, Medical Oncology, Newcastle upon Tyne, United Kingdom; 4 Newcastle University, Academy of Medical Sciences, Newcastle upon Tyne, United Kingdom; 5 Freeman Hospital, Head and Neck surgery, Newcastle upon Tyne, United Kingdom; 6 Freeman Hospital, Plastic surgery, Newcastle upon Tyne, United Kingdom Purpose or Objective To investigate the factors affecting the survival outcomes of patient's with carcinoma of the parotid gland treated with surgery and postoperative radiotherapy (S+RT) or radical radiotherapy (RT) who were unfit or declined surgery. Materials and Methods 77 patients treated with S+RT or RT in Newcastle upon Tyne from January 2009 to December 2019 were included in this retrospective study. Data were collected retrospectively. Survival analysis was performed using log rank analysis and cox regression.