ICHNO-ECHNO 2022 - Abstract Book

S119

ICHNO-ECHNO 2022

0.002

pN+

56

20

100

*3pts did not answer “nº of visits”. MC: medical consult. IQR: Interquartile range. SD: Standard Deviation.

Conclusion COVID19 second wave impacted on HNC diagnosis: 1:10 pts delayed MC due to fear and almost 40% had to consult >3 times to get to a HNC specialist, leading to higher disease stages and less curative-intent treatments. Pts with toxic habits had a greater difficulty in being referred to a specialist.

PO-0187 Long term results of accelerated hypofractionated chemoradiation in oropharyngeal cancer

M. Vreugdenhil 1 , H. Benghiat 1 , T. Beech 2 , I. Boon 3 , C. Boon 4 , J. Glaholm 5 , P. Sanghera 1 , A. Hartley 1

1 Queen Elizabeth Hospital, Hall-Edwards Radiotherapy Research Group, Birmingham, United Kingdom; 2 Queen Elizabeth Hospital, E.N.T., Birmingham, United Kingdom; 3 St James' Hospital, Leeds Cancer Centre, Leeds, United Kingdom; 4 New Cross Hospital, Deansley Centre, Wolverhampton, United Kingdom; 5 Royal Marsden Hospital, Clinical Oncology, London, United Kingdom

Purpose or Objective The COVID 19 pandemic has prompted a re-examination of hypofractionation in head and neck cancer.

Materials and Methods A previously reported cohort of 85 patients treated at a single centre with hypofractionated accelerated intensity modulated radiotherapy and synchronous carboplatin or cetuximab between June 2009 and May 2012 for oropharyngeal squamous cell carcinoma was retrospectively re-examined. Results 7 year Overall Survival (OS) was 63% (95% confidence intervals (52-72%)) with freedom from locoregional recurrence of 79% (68-86%). Patients with p16 positive disease had a significantly better OS in comparison with p16 negative patients (p<0.005) (7 year OS 72% vs. 42%). Patients treated with synchronous carboplatin had superior survival compared with patients treated with synchronous cetuximab (p<0.005) (7 year OS 74% vs. 19%). Incidence of second malignancy and osteoradionecrosis at 7 years was 11 % (5-22%) and 11% (5-23%) respectively. Conclusion This study provides data on long terms outcomes for 4 week accelerated hypofractionated intensity modulated chemo radiation and suggests that a platinum based 4 week combination might be considered when there is extreme pressure on radiotherapy resource. 1 Poznan University of Medical Sciences, Head and Neck Surgery, Pozna ń , Poland; 2 Pozna ń University of Medical Sciences, Head and Neck Surgery, Pozna ń , Poland Purpose or Objective To assess the impact of the Covid-19 pandemic on the diagnosis and treatment of patients at tertiary hospital in Poland Materials and Methods This was a retrospective review of head and neck cancer patients presented to the multidisciplinary tumour board (MTB) during the 12-month period from March 2020 through February 2021 and compared to patients presented to the MTB during the prior, pre-pandemic 12-month period from February 2019 to March 2020. Patient demographic and clinical variables were compared: sex; age at diagnosis; distance from hospital; date of first visit, radiological diagnosis, pathology specimen, MTB meeting, and initiation of primary and adjuvant treatment Results The number of patients presented to the MTB increased by 22% (278 to 340) from the pre-pandemic to the pandemic period. The mean time from MTB presentation to treatment initiation increased significantly from 17.1 to 21.7 days. The mean time from first visit to treatment start increased from 44.7 to 54.4 days. The proportion of patients with early-stage oropharyngeal cancer who underwent primary surgery rose from 47.3% to 86.6%. The percentage of patients who received palliative radiotherapy increased from 20.5% to 32.9%. The proportion of patients who received best supportive care rose from 1.8% to 6.2%. Conclusion One of the most notable findings of this study was the increased time from first visit to treatment initiation, which could negatively impact patient outcomes. The differences in the treatment received in these two periods should be further evaluated to determine their influence on survival PO-0188 The impact of the Covid-19 on the management of H&N cancer patients at a tertiary care institution M. Szewczyk 1 , W. Golusi ń ski 2