ICHNO-ECHNO 2022 - Abstract Book

S23

ICHNO-ECHNO 2022

Conclusion We present the demographics and PROMs for real world larynx cancer patients treated with radical RT. The sex distribution seen in this study reflects that widely documented in the literature. 35% of larynx patients were 70 years or older, 20% had a PS 2 or higher. A substantial proportion of patients in our analysis would not be eligible for clinical trials: Our study provides a ‘real-world’ estimate of how radically treated laryngeal cancer patients fare. Nearly 100% of patients who started a radical course of RT completed the course suggesting age and PS are not necessarily barriers to radical treatment. This is supported by PROMs at 12 months post treatment. Table 1 demonstrates the degree of hoarseness was similar across age groups and PS. The two toxicities with the greatest impact on quality of life are swallow impairment and dry mouth. The swallowing PROM was similar across age groups. There was an increase in the percentage of PS3 patients with severe impairment but this may be due to the low numbers included in this sub-group. Dry mouth was reasonably consistent throughout age and PS cohorts. There were limitations to our study. Due to the nature of the HN5000 study, data was missing from incomplete CRFs (Case Report Forms). Some data was recorded with measurement error. Here we demonstrate that patients aged 70 and over, or with PS of 2 and higher, complete their radical RT courses and report similar levels of toxicity as their younger, fitter peers. This supports the inclusion of these patients in randomised controlled studies so they better reflect the ageing, real world population.

OC-0038 Supportive care needs of caregivers and head and neck cancer patients during 2 years follow-up

K. van Hof 1 , A. Hoesseini 1 , M. Dorr 1 , A. Sewnaik 1 , R. Baatenburg de Jong 1 , M. Offerman 1

1 Erasmus Medical Centre, Otorhinolaryngology and Head and Neck Surgery, Rotterdam, The Netherlands

Purpose or Objective Informal caregivers of head and neck cancer (HNC) patients have a high caregiver burden and often face complex practical caregiving tasks, which may result in unmet supportive care needs. In this study, we identified HNC caregivers’ unmet needs during a 24-month follow-up period, and earmarked informal caregivers prone for unmet supportive care needs. Furthermore, we compared the amount of unmet needs of HNC caregivers and the patients they care for. Materials and Methods This study is part of the multicenter prospective cohort study NETherlands QUality of life and Biomedical cohort studies In Cancer (NetQubic). The Supportive Care Needs Survey (SCNS), Hospital Anxiety and Depression scale (HADS), Caregiver Reaction Assessment (CRA) and EORTC-QLQ-C30 were measured at five time points in 235 caregivers and HNC patients. With mixed effect model analyses the effect over time was evaluated. Results At baseline, 70.3% of the caregivers reported at least one and 44.4% reported >10 unmet supportive care needs, which was significant more than the unmet needs in patients. The highest scores of unmet needs were seen in the domain ‘healthcare & illness related needs’ ( i.e. need for help with assessing information about the patients prognosis, or likely outcome ), especially from baseline up to 6 months after treatment. During follow-up the amount of caregivers with unmet needs decreased significantly over all domains. However, two years after treatment still 28.3% of the caregivers reported at least one unmet need. High depression levels, health problems, financial problems, lower education and higher age of caregivers were associated with more unmet needs. Furthermore, caring for a patient with high unmet needs or a higher disease stage was predictive for more unmet needs in caregivers as well.

Figure 1. the percentage of informal caregivers with no unmet needs, 1-10 unmet needs or >10 unmet needs over time. Unmet needs were defined as a moderate of high need (4&5) on the SCNS-C&P45.