IMRT 2018

LKB model

The Lyman-Kutcher-Burman (LKB) model uses an Equivalent Uniform Dose (EUD)*:

D i = total dose to bin i V i = absolute volume in bin i V tot = total organ volume n = volume effect parameter

Parameter ‘n’ is organ (endpoint) specific

• Low (≈ 0): small volume effect, EUD ≈ max dose

• High (= 1): large volume effect, EUD = mean dose

*Original representation with effective volume rather than EUD

05/06/2018