IMRT Course 2016

IMRT prospective clinical trials: 1

Phase II study to determine if preoperative IMRT is effective in minimizing the dose to skin and subcutaneous tissues used to close the resection site and reduce the risk of wound complications (PMH, Toronto) (1) Dose was reduced to the anticipated surgical flaps by using IMRT planning Primary endpoint: acute wound healing within 120 days Secondary endpoints: limb oedema and fibrosis, bone fracture, limb function, overall patient function 70 patients 2005 – 9 Median 9.5cm, 93% G3, 98% deep to fascia

(1) O'Sullivan B, Griffin AM, Dickie CI, et al. Phase 2 study of preoperative image-guided intensity- modulated radiation therapy to reduce wound and combined modality morbidities in lower extremity soft tissue sarcoma. Cancer 2013; 119 (10): 1878-84.