IMRT Course 2016

IMRT prospective clinical trials: 1

Wound complications in 30.5% (vs 43% in SR2 study) (p=0.2, NS) (1) Commonest sites: buttock, adductor and posterior compartments of thigh Reduced need for tissue transfer for closure Reduced second surgery for wound complications 33% vs 43% (SR2) Trend for increased dose to flap and increased volume of flap receiving 50Gy in patients with wound complications Negative result thought to be due to compromising of flap sparing in order to ensure adequate PTV coverage Grade 2+ fibrosis at 2 years 9.3% vs 31.5% (SR2) Moderate joint stiffness 5.4% vs 17.8% (SR2) (1) O'Sullivan B, Griffin AM, Dickie CI, et al. Phase 2 study of preoperative image-guided intensity- modulated radiation therapy to reduce wound and combined modality morbidities in lower extremity soft tissue sarcoma. Cancer 2013; 119 (10): 1878-84.