IMRT

LARYNX, edema

(2/4)

• Larynx/edema gr 2 :

66 pts, videofluoroscopy assessed, fu=17.4m mean dose or V%> 50 Gy & neck stage (multivariate - Sanguineti et al , IJROBP 2007) V50<27%; mean dose < 43.5 Gy (EQD2)

• Larynx/vocal disfunction :

complex physiology >66 Gy (prescription): decrease in function but not 3D data ( Dornfeld et al, IJROBP 2007)

• Risk factors :

concurrent chemo to high dose RT >double risk of laryngeal edema and vocal dysfunction

Rancati et al , IJROBP, vol, 76, n3, S64-S69