Imaging for early stage breast cancer

HR of Second Solid Cancer comparing RT treated with non-RT treated

RT 23,627

Observations Observations RT 23,627 Non-RT 22,549

HR (95% CI)

Solid Second Cancers

RT-associated sites

15

20

1.17 (0.56-2.44)

Subtotal RT-associated sites Connective tissue Bones & joints Pleura Heart/mediastinum Lung, bronchus, trachea Esophagus

1.27 (1.04-1.55)

3 4 186

292 1

- - -

3

2

1

2.96 (1.17-6.18) 1.34 (1.11-1.61)

16

11

328

226

Subtotal non-RT-associated sites

702

1,102

1.04 (0.94-1.16)

928

1,430

All sites

1.10 (1.01-1.21)

Grantzau et al. Radiotherapy and Oncology 2013; 106: 42-49

4

0

2

3

0.5 1

RT decreased risk

RT increased risk